Publication Detail

14C- and 3H- Tyrosine Incorporation into Ascida Certodes Tunichrome in Vivo.

William E Robinson, Kenneth Kustin, Kimberly Matulef
7 pp.
MITSG 97-14
$3.50 domestic, 5.50 foreign. DOM

Radiolabeled tyrosine is incorporated into newly biosynthesized tunichrome od "Ascidia ceratodes" at a rate comparable to previous findings with phenylalanine. Tyrosine incorporation indicates that formation of the catechol and pyrogallol moieties occurs via the NIH shift pathway. Results are consistent with two alternative hypotheses: tunichromes may be formed either by sequential hydrozylation of di- and tri-peptide precursors, or by selective cleavage of a larger DOPA- or TOPA-containing compound. In either event, hydroxylation may precede formation of tunichrome's carbon backbone.

type: Technical reports

Parent Project

Project No.: 1995-RB-37-PTO
Title: Relationship Between Vanadium and Tunichrome in Sea Squirts